Bouthilette, L.; Aniebok, V.; Colosimo, D.; Brumley, D.; MacMillan, J. B. “Non-Enzymatic Reactions in Natural Product Formation” Chem. Rev. 2022, 122, 14815-14841
Aniebok, V.; Shingare, R.D.; Johnstone, T.C.; Lee, H.; MacMillan, J.B. “Biomimetic Total Synthesis and Investigation of the Non‑Enzymatic Chemistry of Oxazinin A” Angew. Chemie. Int. Ed. 2022, 61, e202208029
Shingare, R.D.; MacMillan, J.B.; Reddy, D.S. “Antibiotic natural product hunanamycin A: Lead identification towards anti-Salmonella agents ” Eur. J. Med. Chem. 2022, 236, 114245-114249
Macho, J.M.; Blue, R.M.; Lee, H.; MacMillan, J.B. “Boron NMR as a Method to Screen Natural Product Libraries for B-Containing Compounds” Org. Lett 2022, 24, 3161-3166
Trebino, M.; Shingare, R.D.; MacMillan, J.B.; Yildiz, F.H “Strategies and Approaches for Discovery of Small Molecule Disruptors of Biofilm Physiology ” Molecules 2021, 26, 4582-4587
Chang, T., et. al. “A method for campus-wide SARS-CoV-2 surveillance at a large public university” PLOS ONE 2021
Shingare, R.D.; Aniebok, V.; Lee, H.; MacMillan, J.B. “Synthesis and Investigation of the Abiotic Formation of Pyonitrins A–D” Org. Lett 2020, 22, 1516-1519
Schwarzer, P.; Flemming, S.; MacMillan, J.B.; Becthold, A. “Draft Genome Sequence of Marine Actinobacterium Streptomyces spinoverrucosus SNB-032 ” Appl. Environ. Microbiol. 2021, 10, e00082-21
Kumar, A.; Russell, R.M.; Pifer, R.; Menezes-Garcia, Z.; Cuesta, S.; Narayanan, S.; MacMillan, J.B. Sperandio, V. “The Serotonin Neurotransmitter Modulates Virulence of Enteric Pathogens ” Cell Host and Microbe 2020, 28, 41-53
McMillan, E. A., et al. “A Genome-wide Functional Signature Ontology Map and Applications to Natural Product Mechanism of Action Discovery” Cell Chem. Biol. 2019, 26, 1380-1392
Gong, J.; Li, W.; Fu, P.; MacMillan, J. B.; De Branbander, J. K. “Isolation, Structure, and Total Synthesis of the Marine Macrolide Mangrolide D” Org. Lett., 2019, 21, 2957-2961
Nichols B.A.; Oswald N.W.; McMillan E.A.; McGlynn K.; Yan J, Kim M.S.; Saha J.; Mallipeddi P.L.; LaDuke S.A.; Villalobos P.A.; Rodriguez-Canales J.; Wistuba I.I.; Posner B.A.; Davis A.J.; Minna J.D.; MacMillan J.B.; Whitehurst, A.W. “HORMAD1 is a negative prognostic indicator in lung adenocarcinoma and specifies resistance to oxidative and genotoxic stress” Cancer Research, 2018, 78, 6196–6208
Kalwat, M. A.; Hwang, I. H; Macho, J. M.; Grzemska, M. G.; Yang, J. Z.; McGlynn, K.; MacMillan, J. B.; Cobb, M. H “Chromomycin A2 Potently Inhibits Glucose-Stimulated Insulin Secretion From Pancreatic β Cells” J Gen Physiol, 2018, 150, 1747-1757
McMillan, E. A., et al. “Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer” Cell, 2018, 173, 864
Vaden, R. M.; Oswald, N. W.; Potts, M. A.; MacMillan, J. B.; White. M. A. “FUSION-Guided Hypothesis Development Leads to the Identification of N6,N6-Dimethyladenosine, a Marine-Derived AKT Pathway Inhibitor” Mar. Drugs 2017, 15, 75.
Fu, P.; MacMillan J. B. “Daryamide Analogues from a Marine-Derived Streptomyces species” J. Nat. Prod. 2017, 86, 1096-1101
Colosimo, D. A.; MacMillan, J. B. “Ammosamides Unveil Novel Biosynthetic Machinery” Cell Chem. Biol. 2016, 23, 144-145
Seitz, T.; Fu, P.; Haut, F. L.; Adam, L.; Habicht, M.; Lentz, D.: MacMillan, J. B.; Christmann,M. “One-Pot Synthesis of 5-Hydroxy-4H-1,3-thiazin-4-ones: Structure Revision, Synthesis, and NMR Shift Dependence of Thiasporine A” Org. Lett. 2016, 18, 3070-3073.
Wang, C.; Niederstrasser, H.; Lin, R.; Jaramillo, J.; Douglas, P.; Li, Y.; Oswald, N.; Zhou, A.; McMillan, E.; Wang, Z.; Zhao, T.; Lin, Z.; Luo. M.; Brekker, R.; Posner, B. A.; MacMillan, J. B.; Huang, G.; Gao, J.; White, M. A. “New small-molecule TFEB pathway agonists that ameliorate metabolic syndrome and extend life-span” Nature Communications, 2017
Kalwat, M.; Wichaidit, C.; Nava Garcia, A.; McCoy, M.; Hwang, I.; McGlynn, K.; MacMillan, J. B.; Posner, B. A.; Cobb, M. “Insulin promoter-driven Gaussia luciferase-based insulin secretion biosensor assay for discovery of β-cell glucose-sensing pathways” ACS Sensors, 2016, 1, 1208-1212
Elkin, S. R.; Oswald, N. W.; Reed, D. K.; Mettlen, M.; MacMillan, J. B.; Schmid, S. L. “Ikarugamycin: A Natural Product Inhibitor of Clathrin-Mediated Endocytosis” Traffic, 2016, 17, 1139-1149
Li, B.; Lowe-Power, T.; Kurihara, S.; Gonzales, S.; Naidoo, J.; MacMillan, J. B.; Allen. C.; Michael A. J. “Functional Identification of Putrescine C-and N-Hydroxylases” ACS Chem. Biol. 2016, 11, 2782-2789
Feng, Y.; Liu, J.; Carrasco, Y.; MacMillan, J. B; De Brabander, J. K. “Rifamycin Biosynthetic Congeners: Isolation and Total Synthesis of Rifsaliniketal, and Total Synthesis of Salinisporamycin and Saliniketals A and B” J. Am. Chem. Soc. 2016, 138, 7130-7142
Sato, S.; Jung, H.; Nakagawa, T.; Pawlosky, R.; Takeshima, T.; Lee, W. R.; Sakiyama, H.; Laxman, S.; Wynn, R. M.; Tu, B. P.; MacMillan, J. B.; De Brabander, J. K.; Veech, R. L.; Uyeda, K., “Metabolite Regulation of Nuclear Localization of Carbohydrate-response Element-binding Protein (ChREBP): Role of AMP as an Allosteric Regulator” J Biol Chem 2016, 291, 10515-10527
Colosimo, D. A.; MacMillan, J. B. “Detailed Mechanistic Study of the Non-enzymatic Formation of the Discoipyrrole Family of Natural Products” J. Am. Chem. Soc. 2016, 138, 2383-2388
Fu, P.; Legako, A.; La, S.; MacMillan, J.B. “Discovery, Characterization and Analog Synthesis of Bohemamine Dimers Generated by Non-enzymatic Biosynthesis” Chem. Eur. J. 2016, 22, 3491-3495
Fisher, K. S.; Das, B.; Kim, H. S.; Clymer, B. K.; Gehring, D.; Smith, D.; Costanzo-Garvey, D.; Fernandez, M.; Brattain, M. G.; Kelly, D.; MacMillan, J. B.; White, M. A.; Lewis, R. E. “AMPK promotes aberrant PGC1β expression to support human colon tumor cell survival” MCB, 2016, 35, 3866 – 3879
Fu, P.; La, S.; MacMillan, J.B. “1,3-Oxazin-6-one Derivatives and Bohemamine-Type Pyrrolizidine Alkaloids from a Marine-Derived Streptomyces spinoverrucosus” J. Nat. Prod. 2016, 79, 455-462
Scheuermann, T. H.; Stroud, D.; Sleet, C. E.; Bayeh, L.; Shokri, C.; Wang, H.; Caldwell, C. G.; Longgood, J.; MacMillan, J. B.; Bruick, R. K.; Gardner, K. H.; Tambar, U. K. “Isoform-Selective and Stereoselective Inhibition of Hypoxia Inducible Factor- 2” J. Med. Chem., 2015, 58, 5930-5941
Korotkov, A.; Lu, H.; Chapman, C. W.; Xue, H.; MacMillan, J. B.; Eastman, A.; Wu, J. “Total Syntheses and Biological Evaluation of Both Enantiomers of Several Hydroxylated Dimeric Nuphar Alkaloids” 2015, 54, 10604-10607
Fu, P.; MacMillan, J. B. “Spithioneines A and B, Two New Bohemamine Derivatives Possessing Ergothioneine Moiety from a Marine-Derived Streptomyces spinoverrucosus” Org. Lett. 2015, 17, 3046-3049
Nguyen, Y.; Nguyen, N.; Rogers, J.; MacMillan, J. B.; Xiang, Y.; Sperandio, V. “Structural and mechanistic roles of novel chemical ligands on the SdiA quorum-sensing transcription regulator” MolBio, 2015, 6, e02429-14
Fu, P.; MacMillan, J.B. “Thiasporines A–C, Thiazine and Thiazole Derivatives from a Marine-Derived Actinomycetospora chlora”. Journal of Natural Products. 2015, 78, 548-551
Chen, J.; Koswatta, P.; DeBergh, J. R.; Fu, P.; Pan, E.; MacMillan, J.B.; Ready, J. M. “Structure Elucidation of Nigricanoside A Through Enantioselective Total Synthesis”. Chem. Sciences, 2015, 6, 2932-2937
Potts, M.A., Rosales, T. I.; McMillan, E. A.; Kim, H.; Ou, Y.; Toombs, J. E.; Brekken, R. A.; MacMillan, J. B.; White, M.A. “Exceptional responders to didemnin B illuminate mechanism of action and pharmacogenomic biomarkers for antineoplastic activity” Nat. Chem. Biol. 2015, 11, 401-408
Fu, P.; Johnson, M.; Posner, B.; MacMillan, J. B. “Cytotoxic Arylamine Derivatives from a Marine-Derived Streptomyces carpaticus” J. Nat. Prod. 2014, 77, 1245-1248
Fu, P.; Jamison, M.;Oswald, N.; La, S.; MacMillan, J. B. “Inducamides A-C, chlorinated alkaloids from an RNA polymerase mutant strain of Streptomyces sp.” Org. Lett. 2014, 16, 5656-5659
Derebe, M, Zlatkov; C. M.; Gattu, S.; Ruhn, K. A.; Vaishnava, S.; Diehl, G. E.; MacMillan, J. B.; Williams, N. S.; Littman, D. R.; Hooper, L. V. “Serum amyloid A is a retinol binding protein that transports retinol during bacterial infection” eLIFE, 2014, 3, e03206
Hu, Y.; Potts, M. A.; Herrera, M.; White, M. A.; MacMillan, J. B. “Discoipyrroles A-D, Migration Inhibitors from a marine-derived Bacillus hunanensis” J. Am. Chem. Soc. 2013, 135, 13387−13392
Potts, M.B.; Kim, Y.; Fisher, K. W.; Hu, Y.; Carrasco, Y.; Ou, Y-H.; Herrera, M.; Cubillos, F.; Xiao, G.; Hofree, M.; Ideker, T.; Xie, Y.; Lewis, R. E.; MacMillan, J. B.*; White, M. A.* “Broad-scale mode-of-action annotation of natural product perturbations by functional signature ontology (FUSION)” Science Signaling 2013, 6, ra90
Hu, Y.; Wang, K.; MacMillan, J. B. “Hunanamycin A, an Antibiotic from a Marine-derived Bacillus hunanensis” Org. Lett. 2013, 15, 390-393
Rogers, J. L.; Bayeh, L.; Scheurmann, T. H.; Longgood, J.; Key, J.; Naidoo, J. Melito, L.; Shokri, C.; Frantz, D. E.; Bruick, R. K.; Gardner, K. H.*; MacMillan, J. B.*; Tambar, U. K.* “Development of Inhibitors of the PAS-B Domain of the HIF-2aTranscription Factor” J. Med. Chem. 2013, 56, 1739-1747
Sun, Q.; Carrasco, Y. P.; Hu, Y.; Guo, X.; Mirzaei, H.; MacMillan, J. B.; Chuk, Y-M. “Nuclear export inhibition through covalent conjugation and hydrolysis of leptomycin B by CRM1” Proc. Natl. Acad. Sci. USA 2013, 110, 1303-1308
Pan, E.; Oswald, N.; Life, J. M.; Posner, B. A.; MacMillan, J. B. “Precursor-Directed Generation of Amidine Containing Ammosamide Analogs: Ammosamides E-P” Chemical Sciences 2013, 4, 482-488
Hu, Y.; Martinez, E. D.; MacMillan, J.B. “Anthraquinones from a Marine-Derived Streptomyces spinoverrucosus” J. Nat. Prod. 2012, 75, 1759-1764
Rogers, J. L.; MacMillan, J.B. “A Labeled Substrate Approach to Discovery of Biocatalytic Reactions: A Proof of Concept Transformation with N-Methylindole” J. Am. Chem. Soc. 2012, 19, 12378-12380
Pan, E.: Jamison, M.; Yousufuddin, M.; MacMillan, J.B. “Ammosamide D, an oxidatively ring opened ammosamide analog from a marine-derived Streptomyces variabilis” Org. Lett. 2012, 14, 2390-2393
Hu, Y.; Legako, A.G.; Espindola A.P.; MacMillan J.B. “Erythrolic Acids A-E, Meroterpenoids from a Marine-derived Erythrobacter sp.” J. Org. Chem. 2012. 77, 3301-3307
Hu, Y.; MacMillan, J.B. “A new peptide isolated from a marine derived Streptomyces bacillaris” Nat. Prod. Comm. 2012, 7, 211-214
Hu Y., MacMillan J.B. Erythrazoles A-B, “Cytotoxic Benzothiazoles from a Marine-derived Erythrobacter sp.” Org. Lett. 2011, 13, 6580-6583
Hu Y.; Espindola A.P.; Stewart N.A.; Wei S.; Posner B.A.; MacMillan J.B.“Chromomycin SA analogs from a marine-derived Streptomyces sp.” Bioorg. Med. Chem. 2011, 19, 5183-5189
Cancer Target Discovery and Development Network, Schreiber, S.L.; Shamji, A.F.; Clemons, P.A.; Hon, C.; Koehler, A.N.; Munoz, B.; Palmer, M.; Stern, A.M.; Wagner, B.K.; Powers, S.; Lowe, S.W.; Guo, X.; Krasnitz, A.; Sawey, E.T.; Sordella, R.; Stein, L.; Trotman, L.C.; Califano, A.; Dalla-Favera, R.; Ferrando, A.; Iavarone, A.; Pasqualucci, L.; Silva, J.; Stockwell, B.R.; Hahn, W.C.; Chin, L.; DePinho, R.A.; Boehm, J.S.; Gopal, S.; Huang, A.; Root, D.E.; Weir, B.A.; Gerhard, D.S.; Zenklusen, J.C.; Roth, M.G.; White, M.A.; Minna, J.D.; MacMillan, J.B.; Posner, B.A. “Towards patient-based cancer therapeutics” Nat Biotechnol. 2010 9, 904-906
Espindola A.P, Crouch R, DeBergh J.R, Ready J.M, MacMillan J.B. “Deconvolution of complex NMR spectra in small molecules by multifrequency homonuclear decoupling (MDEC)” J. Am. Chem. Soc. 2009 131, 15994-1599
Chiu Y.H., MacMillan J.B., Chen Z.J. “RNA polymerase III detects cytosolic DNA and induces type I interferon’s through the RIG-I pathway” Cell. 2009,138, 576-591